Type 2 diabetes means the pancreas doesn’t produce enough insulin to control blood sugar ranges or the insulin it does produce just isn’t taken up by cells. Insulin regulates blood sugar – the principle type of sugar present in blood. Deprived of this mechanism, blood sugar ranges can soar to harmful ranges. Fortunately, there may be an efficient countermeasure at hand.
According to findings introduced Thursday at The Endocrine Society’s 97th annual assembly in San Diego, extract of onion bulb, Allium cepa, strongly lowered excessive blood glucose (sugar) and complete levels of cholesterol in diabetic rats when given with the antidiabetic drug metformin.
“Onion is cheap and available and has been used as a nutritional supplement,” stated lead investigator Anthony Ojieh, MBBS (MD), MSc, of Delta State University in Abraka, Nigeria.
“It has the potential for use in treating patients with diabetes.”
To three teams of rats with medically induced diabetes, Mr Ojieh and his colleagues gave metformin and ranging doses of onion extract- 200, 400 and 600 milligrams per kilograms of physique weight every day (mg/kg/day)- to see if it will improve the drug’s results.
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They additionally gave metformin and onion extract to 3 teams of nondiabetic rats with regular blood sugar, for comparability.
Two management teams, one nondiabetic and one diabetic, obtained neither metformin nor onion extract.
Another two teams (one with diabetes, one with out) obtained solely metformin and no onion extract. Each group contained 5 rats.
Two doses of onion extract, 400 and 600 mg/kg/day, strongly decreased fasting blood sugar ranges in diabetic rats by 50 % and 35 %, respectively, in contrast with “baseline” ranges in the beginning of the study earlier than the rodents obtained onion extract, Mr Ojieh reported.
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Allium cepa additionally reportedly lowered the whole ldl cholesterol degree in diabetic rats, with the 2 bigger doses once more having the best results.
Onion extract led to a rise in common weight amongst nondiabetic rats however not diabetic rats.
“Onion is not high in calories,” Mr Ojieh stated. “However, it seems to increase the metabolic rate and, with that, to increase the appetite, leading to an increase in feeding.”
“We need to investigate the mechanism by which onion brought about the blood glucose reduction,” Mr Ojieh stated. “We do not yet have an explanation.”
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The study, which additionally concerned scientists from Cranfield University within the UK, discovered that the brown pores and skin and exterior layers of onions comprise helpful quantities of fibre and flavonoids, and that the bulbs comprise sulphurous compounds and fructans.
The analysis confirmed that as a result of the brown pores and skin of the onion was excessive in dietary fibre it might be used as a useful ingredient, and that two outer fleshy layers additionally comprise fibre and flavonoids, and have a excessive antioxidant capability.
Researcher Vanesa Benitez commented: “One solution could be to use onion waste as a natural source of ingredients with high functional value, because this vegetable is rich in compounds that provide benefits for human health.”
She added: “Eating fibre reduces the risk of suffering from cardiovascular disease, gastrointestinal complaints, colon cancer, type 2 diabetes and obesity.”